The inhibitory receptors PD1, Tim3, and A2aR are highly expressed during mesoCAR T cell manufacturing in advanced human epithelial ovarian cancer
Abstract Background Chemotherapy and surgery have been the mainstays of epithelial ovarian cancer (EOC) treatment so far.Cellular immunotherapies such as CAR T cell therapy have recently given hope of a cure for solid tumors like EOC.However, extrinsic factors associated with the CAR T cell manufacturing process and/or intrinsic dysregulation of pa